A hepatitis C-positive patient with new onset of nephrotic syndrome and systemic amyloidosis secondary to common variable immunodeficiency

A hepatitis C-positive patient with new onset of nephrotic syndrome and systemic amyloidosis secondary to common variable immunodeficiency

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Common variable immunodeficiency (CVID) is a heterogenous group of predominantly antibody-deficiency disorders that make up the greatest proportion General Wound Care - General Purpose Dressings of patients with symptomatic primary hypogammaglobulinemia.The rare coincidence of amyloidosis and hypogammaglobulinemia has been reported previously.Contrary to the usual insidious, slowly progressive disease following hepatitis C infection, a rapidly progressive cirrhotic form can develop in hypogammaglobulinemic patients.

We report a HCV-positive patient with a new onset of nephrotic syndrome and systemic amyloidosis secondary to CVID.Blood analyses showed serum creatinine of 1.8 mg/dL and serum albumin of 3.

1 gm/dL; 24-h urinary protein was 11 Gloves 800 mg/day.Serum immunoglobulin levels were IgG 340 mg/dL, IgM 18 mg/dL, IgA 11 mg/dL.Duodenal biopsy revealed AA-type amyloidosis with potassium permanganate and Congo red staining.

After a month of antiproteinuric therapy, the proteinuria was reduced to 3350 mg/day.